Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0

Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0

Cytochromes P450

This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.

Dansette, Patrick M. (editor)
Werck, Danièle (editor)

https://directory.doabooks.org/handle/20.500.12854/76512

MDPI - Multidisciplinary Digital Publishing Institute

2021

Sulistiorini

https://creativecommons.org/licenses/by/4.0/

1. Preface to ”Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0” 2. Lydia Benkaidali, Fran¸cois Andr´e, Gautier Moroy, Bahoueddine Tangour, Fran¸cois Maurel and Michel Petitjean Four Major Channels Detected in the Cytochrome P450 3A4: A Step toward Understanding Its Multispecificity Reprinted from: Int. J. Mol. Sci. 2019, 20, 987, doi:10.3390/ijms20040987 3. Irina F. Sevrioukova Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6’,7’-Dihydroxybergamottin Reprinted from: Int. J. Mol. Sci. 2019, 20, 4245, doi:10.3390/ijms20174245 4. Ghulam Mustafa, Prajwal P. Nandekar, Neil J. Bruce and Rebecca C. Wade Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19 Reprinted from: Int. J. Mol. Sci. 2019, 20, 4328, doi:10.3390/ijms20184328 . 5. William R. Arnold, Susan Zelasko, Daryl D. Meling, Kimberly Sam and Aditi Das Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling Reprinted from: Int. J. Mol. Sci. 2019, 20, 4626, doi:10.3390/ijms20184626 6. Diana Campelo, Francisco Esteves, Bernardo Brito Palma, Bruno Costa Gomes, Jos´e Rueff, Thomas Lautier, Philippe Urban, Gilles Truan and Michel Kranendonk Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450 Reprinted from: Int. J. Mol. Sci. 2018, 19, 3914, doi:10.3390/ijms19123914

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DOI
10.3390/books978-3-0365-0257-1
ISBN
9783036502564, 9783036502571